doi: 10.1016/0896-6273(95)90232-5, Butner, K. A., and Kirschner, M. W. (1991). However, plasma and serum phosphate levels do not necessarily reflect whole-body phosphorus content [ 1, 11 ]. Proc. Dr. Ornstein and his group reviewed the charts of 69 anorexia nervosa patients (66 females, 3 males) admitted to an inpatient adolescent medical unit between July 1998 and July 2001. (2005). doi: 10.1093/geronb/57.1.P47, Li, T., Xie, Y., Bowe, B., Xian, H., and Al-Aly, Z. U.S.A. 107, 9490–9495. β-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. All participants underwent standardized clinical assessment by trained psychiatrists, based on the KBASE protocol, which corresponded with the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K) (Lee et al., 2002). Sci. Res. 12, 723–738. Dis. These results suggest that the serum level of phosphorus may be used as a blood-based biomarker for PiB positivity or AD in conjunction with ApoE ε4 genotype for cognitively impaired population. J. J. (2009). (2002). Further studies are needed with larger sample sizes to examine the effects of more diverse elements and indices involved in phosphorus metabolism and nutritional states such as the diet pattern. doi: 10.1016/j.pneurobio.2015.12.004, Hane, F., Tran, G., Attwood, S. J., and Leonenko, Z. Further experiments are needed to elucidate the underlying mechanism. Individuals with MCI (age 55–90 [inclusive]) met the following criteria: (a) memory complaint reported by themselves or reported by an informant or a clinician; (b) presence of objective memory impairment; (c) intact functional activities; and (d) non-demented. Table 1. (2004). Soc. Microbiol. Acta Neuropathol. At this degree of renal insufficiency, changes in dietary phosphate intake can contribute to the degree of hyperphosphatemia. A similar correlation was observed when the two groups were combined (r = −0.24, df = 178, p = 0.001; Figure 1B, left). Relations of serum phosphorus levels to echocardiographic left ventricular mass and incidence of heart failure in the community. doi: 10.1002/jnr.10355, Murphy, M. P., and LeVine, H. III. In this study, we investigated whether serum level of phosphorus is associated with cerebral deposition of Aβ in cognitively impaired subjects. Age and sex were adjusted and global cerebral amyloid burden (SUVR) was natural log transformed to normalize variance. Background: This study aimed to evaluate the predictive performance of low serum calcium and phosphorus in discriminative diagnosis of the severity of COVID-19 patients. Science 330:1774. doi: 10.1126/science.1197623, McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R. Jr., Kawas, C. H., et al. All statistical analyses were performed using Medcalc 17.2 (Medcalc Software, Ostend, Belgium). The partial correlation analyses revealed a significant correlation between the serum level of phosphorus and the deposition of cerebral amyloid in both MCI (r = −0.23, df = 105, p = 0.018) and ADD (r = −0.26, df = 69, p = 0.031) groups (Figure 1A). B Psychol. Low Serum Phosphorus Correlates With Cerebral Aβ Deposition in Cognitively Impaired Subjects: Results From the KBASE Study - PubMed Alzheimer's disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. Brain 135, 2126–2139. DOCTORS: Click … Greatest risk at very low IBW. Analysis and interpretation of data by J-CP, S-HH, MB, DY, JL, DL, and IM-J. doi: 10.1016/j.neuroimage.2003.11.010, Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., et al. When the results are too high or too low, it's a sign that something's not right. 55, 306–319. A recent study also showed that phosphorus dendrimer interacts with amyloid peptide and microtubule associated protein (MAP) tau in such a way that it affects the aggregation process of Aβ and tau (Wasiak et al., 2012). The cerebral accumulation of Aβ is closely associated with cellular toxicity, synaptic dysfunction, aberrant neuronal activity, and destabilization of neural networks (Palop and Mucke, 2010). Zinc ions promote Alzheimer Aβ aggregation via population shift of polymorphic states. Hypophosphataemia. Brain aluminum, magnesium and phosphorus contents of control and Alzheimer-diseased patients. Age, sex, and ApoE ε4 carrier status were included as covariates. Alzheimers Dement. AUC value was significantly enhanced by combining the two variables (AUC, 0.757–0.800; Figure 2A, gray and black line; Figure 2B, p = 0.0343, comparison of ROC curves analysis). doi: 10.1093/geronb/gbs077, Querfurth, H. W., and LaFerla, F. M. (2010). Figure 1. A total of 182 subjects (109 MCI subjects and 73 ADD subjects) were included in this study. Nutr. Nat. (1988). doi: 10.1371/journal.pone.0059005, Hardy, J. But it can’t help to diagnose the condition of the patient, hence the doctor will need to perform a few more tests to determine the cause of abnormal phosphorus (serum) test results. Are age-related neurodegenerative diseases linked with various types of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer disease... T. ( 2016 ) Ghiso, J., and JL over 60 10.1093/geronb/57.1.P47,,..., Park, Han, Byun, Yi, Lee and Mook-Jung for the KBASE Research Group deposition! 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